The crash occurred just north of Country Meadows Lane in Laurel shortly before 9:45 p.m., according to the Howard County Police Department.
A 1995 Chevy 1500 was heading northbound when it crossed the median and struck a southbound 2007 Pontiac Solstice. The Pontiac then hit a 2022 Hyundai Accent, while debris from the crash hit a 2022 Toyota Camry.
The man driving the Pontiac was pronounced dead at the scene, police said.
Two other drivers were taken to nearby hospitals for treatment of undisclosed injuries.
Route 1 was shut down in both directions between Whiskey Bottom Road and Maier Road for about four hours.
The crash remains under investigation.
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